Omdat prehabilitatie een relatief nieuwe interventie is, wordt er volop onderzoek gedaan naar de effecten ervan. Op dit tabblad staan lopende en lopende studies weergegeven.
Jaarlijkse onderzoeksronde
Stichting Fit4Surgery organiseert elk jaar samen met Nationaal Fonds tegen Kanker een onderzoeksronde om onderzoek naar prehabilitatie te stimuleren. De onderzoeksronde van 2024 start in november. Daarover volgt later dit jaar meer informatie.
Lopende wetenschappelijke studies in Nederland
- ‘Proof-of-concept’ study concerning the feasibility and patient preferences and experiences of early rehabilitation during chemoradiotherapy among patients with stage III non-small cell lung cancer
Maastricht UMC
PI: Maryska Janssen-Heijnen - A qualitative stakeholder analysis of expectations, preferences, barriers and facilitators for prehabilitation before lung cancer surgery,
Maastricht UMC
PI: Maryska Janssen-Heijnen - Feasibility of a teleprehabilitation study in high-risk patients with colon or rectal cancer undergoing elective surgery: a pilot study
VieCurie
PI: Ruud Franssen onder leiding van Prof. Dr. Maryska Janssen-Heijnen - Multicenter pilot study to determine the feasibility of a multimodal prehabilitation program in patients with non-small cell lung cancer undergoing anatomical lung resection (2019.058)
Albert Schweitzer Ziekenhuis en Maxima Medisch Centrum
PI: dr. Geertruid M.H. Marres - Multimodal intensive prehabilitation in high impact surgery (NL8699)
Radboudumc
PI: prof. dr. Kees van Laarhoven
Gepubliceerde wetenschappelijke studies over prehabilitatie
- European Society of Organ Transplantation (ESOT) Consensus Statement on Prehabilitation for Solid Organ Transplantation Candidates;
Coby Annema, Stefan De Smet, Ellen M. Castle, Yasna Overloop, Joost M. Klaase, Tania Janaudis-Ferreira, Sunita Mathur, Evangelia Kouidi, Maria Jose Perez Saez, Christophe Matthys, Fabienne Dobbels, Pisana Ferrari, Justyna Gołębiewska, Anna Mrzljak, Peter Girman, Michael Perch, Victor Lopez-Lopez, Colin White, Dmytro Koval, Sharlene Greenwood, and Diethard Monbaliu on behalf of the ESOT Guidelines Taskforce. 2023 July 21
(European Society of Organ Transplantation (ESOT) Consensus Statement on Prehabilitation for Solid Organ Transplantation Candidates) - Treatment of iron deficiency in patients scheduled for pancreatic surgery: implications for daily prehabilitation practice in pancreatic surgery
Allard G. Wijma, Michele F. Eisenga, Maarten W. Nijkamp, Frederik J. H. Hoogwater and Joost M. Klaase for Perioperative Medicine. 2023
(Treatment of iron deficiency in patients scheduled for pancreatic surgery: implications for daily prehabilitation practice in pancreatic surgery) - Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer SurgeryThe PREHAB Randomized Clinical Trial; Charlotte Johanna Laura Molenaar, MD; Enrico Maria Minnella, MD, PhD; Miquel Coca-Martinez, MD, MSc,; David Wouter Gerard ten Cate, MD; Marta Regis, PhD; Rashami Awasthi, MSc; Graciela Martínez-Palli, MD, PhD; Manuel López-Baamonde, MD; Raquel Sebio-Garcia, MSc, PhD; Carlo Vittorio Feo, MD,; Stefanus Johannes van Rooijen, MD, PhD; Jennifer Marijke Janneke Schreinemakers, MD, PhD; Rasmus Dahlin Bojesen, MD, PhD; Ismail Gögenur, MD, PhD; Edwin R. van den Heuvel, MSc, PhD; Francesco Carli, MD, MPhil; Gerrit Dirk Slooter, MD, PhD; for the PREHAB Study Group. JAMA Surgery 2023 March 29 (https://jamanetwork.com/journals/jamasurgery/fullarticle/2803109?guestAccessKey=836823e2-fcda-4073-8d42-45d7b42159fc&utm_source=jps&utm_medium=email&utm_campaign=author_alert-jamanetwork&utm_content=author-author_engagement&utm_term=1m)
- Prehabilitation in major abdominal surgery: risk stratification and optimising perioperative care; van Wijk L, Klaase J, Buis C. University of Groningen 2022 June 22 (https://research.rug.nl/nl/publications/prehabilitation-in-major-abdominal-surgery-risk-stratification-an)
- Preoperative optimization of diagnostic work-up and physical fitness predicts and improves outcome of patients with colorectal cancer; Berkel AEM, van Meeteren N, Klaase J, Bongers B. Maastricht University. 2022 Jan 20 (https://cris.maastrichtuniversity.nl/en/publications/preoperative-optimization-of-diagnostic-work-up-and-physical-fitn)
- A multimodal prehabilitation program in high-risk patients undergoing elective resection for colorectal cancer: A retrospective cohort study; de Klerk M, van Dalen DH, Nahar-van Venrooij LMW, Meijerink WJHJ, Verdaasdonk EGG; Eur J Surg Oncol. 2021 May 29
- Personalised Prehabilitation in High-risk Patients Undergoing Elective Major Abdominal Surgery: A Randomized Blinded Controlled Trial; Barberan-Garcia A, Ubré M, Roca J, Lacy AM, Burgos F, Risco R, Momblán D, Balust J, Blanco I, Martínez-Pallí G; Ann Surg. 2018 Jan;267(1):50-56
- Comprehensive multidisciplinary care program for elderly colorectal cancer patients: “From prehabilitation to independence”; Souwer ETD, Bastiaannet E, de Bruijn S, Breugom AJ, van den Bos F, Portielje JEA, Dekker JWT; Eur J Surg Oncol. 2018 Dec;44(12):1894-1900
- Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation; van Rooijen S, Carli F, Dalton S, Thomas G, Bojesen R, Le Guen M, Barizien N, Awasthi R, Minnella E, Beijer S, Martínez-Palli G, van Lieshout R, Gögenur I, Feo C, Johansen C, Scheede-Bergdahl C, Roumen R, Schep G, Slooter G; BMC Cancer. 2019 Jan 22;19(1):98
- Effect of Multimodal Prehabilitation vs Postoperative Rehabilitation on 30-Day Postoperative Complications for Frail Patients Undergoing Resection of Colorectal Cancer: A Randomized Clinical Trial; Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M, Stein B, Charlebois P, Ghitulescu G, Morin N, Jagoe T, Scheede-Bergdahl C, Minnella EM, Fiore JF Jr; JAMA Surg. 2020 Mar 1;155(3):233-242
- Improved Disease-free Survival After Prehabilitation for Colorectal CancerSurgery; Trépanier M, Minnella EM, Paradis T, Awasthi R, Kaneva P, Schwartzman K, Carli F, Fried GM, Feldman LS, Lee L; Ann Surg. 2019 Sep;270(3):493-501
- Effects of Community-based Exercise Prehabilitation for Patients Scheduled for Colorectal Surgery With High Risk for Postoperative Complications: Results of a Randomized Clinical Trial; Berkel AEM, Bongers BC, Kotte H, Weltevreden P, de Jongh FHC, Eijsvogel MMM, Wymenga ANM, Bigirwamungu-Bargeman M, van der Palen J, van Det MJ, van Meeteren NLU, Klaase JM; Ann Surg. 2021 Jan 11
Proefschriften over prehabilitatie
- Dr. Emma Bruns – 2019
Towards resilience: prehabilitation in elderly with colorectal cancer
https://www.publicatie-online.nl/uploaded/flipbook/136342-Emma-Bruns/ - Dr. Stefan van Rooijen – 2018
Colorectal cancer surgery: clinical improvements introducing prehabilitation
https://www.werkgroepcoloproctologie.nl/wp-content/uploads/2018/10/Colorectal-Cancer-Surgery-Stefan-van-Rooijen.pdf
Jaarlijkse onderzoeksronde
Jaarlijks organiseert Fit4Surgery samen met Nationaal Fonds tegen Kanker een subsidieronde ter bevordering van onderzoek naar prehabilitatie. Klik hier voor meer informatie over de huidige onderzoeksronde.